Which 49ers props actually win together — and which quietly fight each other? Everything below is computed from 85 real games (2021–2025 seasons, recency-weighted). No picks, no locks: just the historical relationships, with sample sizes.
In 2025 the 49ers averaged 25.7 points per game and the game total went Over in 10 of 17 games (59%). Over the full five-season sample the Over hit 54% of the time.
Chemistry is the recency-weighted correlation between two props' game-by-game results. Green pairs rise and fall together — one coherent story. The joint column counts games where both beat their typical line.
| Leg A | Leg B | Chemistry | Both Over |
|---|---|---|---|
| Jauan Jennings Rec Yds | Jauan Jennings Receptions | +0.86 | 16 of 59 |
| George Kittle Rec Yds | George Kittle Receptions | +0.72 | 22 of 64 |
| Brock Purdy Pass Yds | George Kittle Rec Yds | +0.49 | 11 of 39 |
| Brock Purdy Rush Yds | George Kittle Receptions | +0.49 | 7 of 37 |
| Brock Purdy Pass TDs | Christian McCaffrey Rush Yds | +0.42 | 20 of 51 |
| Brock Purdy Pass Yds | Christian McCaffrey Rec Yds | +0.38 | 5 of 32 |
| Brock Purdy Pass Yds | George Kittle Receptions | +0.37 | 8 of 39 |
| Brock Purdy Rush Yds | Jauan Jennings Rec TDs | +0.37 | 5 of 41 |
Negative chemistry is not a warning — flip one leg to the Under and a fighting pair becomes a coherent story. How Under legs work in an SGP →
| Leg A | Leg B | Chemistry | Both Over |
|---|---|---|---|
| Brock Purdy Pass TDs | Christian McCaffrey Rec Yds | -0.23 | 8 of 51 |
| Christian McCaffrey Rec Yds | Jauan Jennings Rec TDs | -0.25 | 3 of 51 |
| Christian McCaffrey Rush TDs | Jauan Jennings Rec Yds | -0.26 | 9 of 49 |
| Christian McCaffrey Rush Att | Jauan Jennings Rec Yds | -0.31 | 5 of 49 |
Estimated lines are trailing medians of recent production — a stable reference point, not a live sportsbook quote.
| Prop | Est. Line | Wtd Median | Over % '25 | Over % 5yr | Games |
|---|---|---|---|---|---|
| Jauan Jennings Rec TDs | 0.5 | 0.0 | 47% | 20% | 80 |
| Brock Purdy Pass TDs | 0.5 | 1.0 | 47% | 55% | 64 |
| Brock Purdy Interceptions | 0.5 | 0.0 | 35% | 33% | 64 |
| Christian McCaffrey Rush Att | 19.5 | 15.0 | 53% | 23% | 64 |
| Christian McCaffrey Rush TDs | 0.5 | 0.0 | 47% | 39% | 64 |
| Christian McCaffrey Rec TDs | 0.5 | 0.0 | 35% | 25% | 64 |
| George Kittle Rec Yds | 66.5 | 67.0 | 60% | 48% | 64 |
| George Kittle Receptions | 5.5 | 4.0 | 50% | 36% | 64 |
| Jauan Jennings Rec Yds | 40.5 | 40.0 | 53% | 39% | 59 |
| Jauan Jennings Receptions | 3.5 | 4.0 | 67% | 36% | 59 |
| Christian McCaffrey Rush Yds | 56.5 | 66.0 | 53% | 57% | 51 |
| Christian McCaffrey Rec Yds | 52.5 | 43.0 | 53% | 35% | 51 |
| Brock Purdy Pass Yds | 276.5 | 260.0 | 56% | 42% | 43 |
| Brock Purdy Rush Yds | 15.5 | 13.0 | 56% | 39% | 41 |
| Ricky Pearsall Rec Yds | 84.5 | 46.0 | 50% | 29% | 14 |
| Kendrick Bourne Rec Yds | 31.5 | 27.0 | 50% | 50% | 12 |
| Jake Tonges Rec Yds | 30.5 | 31.0 | 56% | 56% | 9 |
Build a 49ers parlay with live chemistry →
The interactive Parlay Architect recalculates everything — including with injured players excluded.
Based on 85 games across five seasons, the strongest positive relationships on the 49ers are shown in the table above — pairs of props that historically go Over together. Positive chemistry means the legs tell one story; the joint hit column shows how often both actually landed in the same game.
Across the last five seasons the Over hit in 46 of 85 49ers games (54%), and 10 of 17 (59%) in the 2025 season. Totals context matters for every SGP: over-leaning games favor passing stacks, under-leaning games favor rush attempts and Unders.
Every figure is computed from complete game-level box scores for all 32 teams across the 2021–2025 seasons — 85 games for the 49ers alone. Recent seasons are weighted more heavily. Lines shown are trailing medians, not live sportsbook lines. Sample sizes are always displayed.
49ers player profiles: Jauan Jennings · Brock Purdy · Christian McCaffrey · George Kittle · Ricky Pearsall · Kendrick Bourne
NFC West rivals: Arizona Cardinals · Los Angeles Rams · Seattle Seahawks
Guides: What is a correlated parlay? · SGP strategy that respects math · Why parlays lose money